Risk Estimation and Pedigree Analysis
نویسندگان
چکیده
منابع مشابه
Risk Estimation and Pedigree Analysis
For geneticists, an assessment of the likelihood of a particular woman developing breast cancer, given her pedigree, is a necessary but not sufficient prerequisite for the provision of advice about her management. While a variety of methods of risk assessment have been proposed over the last ten years, based on data from a variety of sources, geneticists should only feel comfortable using metho...
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We report on the design and implementation of a prototype program, GENINFER , to assist genetic counselors in evaluating the risk of recurrence of genetic disorders based on the analysis of family pedigrees. The present version of the program integrates a convenient graphical interface that permits counselors to draw, examine and modify family pedigrees and to enter information relevant to ri...
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In .an~ysesofthefamilialidistributiOn.9~/~~neti£)t:rflits,alikelihoodappr~a(;h is usually taken-.It is o~~nnecessarythatsu(;h likelihood$beconclition~ upon aspects 9fthepopulation stl'u.(;ture and Sampling procedure. ·lnthefieldof>llleclicalgeneticanalyses,efficiency and information areiimpormntcritena, to bebalancedi ~gflinst the requirements of robustness and simplicity of application. In man...
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In this study, pedigree data of 7170 lambs produced from 177 rams and 2182 ewes collected during 1989 to 2009 in the Shirvan Kordi sheep breeding station, were used for calculating inbreeding coefficients. The impact of inbreeding on the studied traits was investigated by including inbreeding coefficients for each animal as a covariate in the animal model. Average inbreeding coefficient of the ...
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The high-risk pedigree (HRP) design is an established strategy to discover rare, highly-penetrant, Mendelian-like causal variants. Its success, however, in complex traits has been modest, largely due to challenges of genetic heterogeneity and complex inheritance models. We describe a HRP strategy that addresses intra-familial heterogeneity, and identifies inherited segments important for mappin...
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ژورنال
عنوان ژورنال: Disease Markers
سال: 1999
ISSN: 0278-0240,1875-8630
DOI: 10.1155/1999/483754